Program

Time	Thursday 23 May	Friday 24 May	Saturday 25 May	Sunday 26 May	Monday 27 May
9:00		Neera Borkakoti and Georges Tsoucaris Welcome and Introduction	Aled Edwards Aspects of Multiplex Cloning	Manfred Sippl Prediction of Protein Structure and Function	Free time
10:00		Herb Hauptman X-Ray Crystallography: A History of Ideas	Gert Vriend The Power of Data	Colin Groom Structure Assisted Target Selection	Free time PP1s Go Up
11:00	BREAK
11:30		Tom Blundell Impact of Genomic Sequencing and High Throughput Crystallography on the Drug Discovery Process	Burkhard Rost Predicting Protein Function	JanetThornton From Structure to Function	Jenny Glusker Milestones in Crystallography and Drug Design
12:30	LUNCH
14:30 to 16:30	A R R I V A L	Introduction to Workshops(W1-W8) 10-20 mins each	W1 : Crystallisation (in San Rocco) W2 : PDB (in San Domenico) W3 : FlexX (in San Domenico)	W4 : CSD (in San Rocco) W5: Northwestern DOCK (in San Domenico)	Naomi Siew Genomic ORFans Past Present and Future Frederik Deroose Structure-Based Computer Screening Michal Linial: In search of new structures
		W1: Naomi Chayen Crystallisation
		W2:Bohdan Schneider PDB
		W3: Matthias Rarey FlexX
		W4: Paul Edgington CSD
		W5: John Irwin Northwestern DOCK
		W6: Gert Vriend WHATCHECK		S y m m e t r y
		W7: Janet Thornton BioInformatics
		W8:JennyGlusker Metal Ions
16:30	BREAK
17:00		*Introductory Talks :* Jenny Glusker X Ray Crystallography	Jean-Michel Rondeau HTS Hits and Protein Crystallography		Talks from Posters/ Workshops
17:00					Talks from Posters/ Workshops
17:45		*Peter Goodford* Drug Design	Jordi Quintana Pharmacophores Modeling		Talks/Group Discussions
18:30	BREAK
19:00	Social	Social	Free Evening		Posters & Pizza (PP1)

Time	Tuesday 28 May	Wednesday 29 May	Thursday 30 May	Friday 31 May
9:00	Gerhard Klebe Structure and Energetics Aspect of Binding in Drug Design	Andrew Ferguson Structural Biology of Membrane Proteins	Ted N.Baker New Drug Targets TB	Nenad Ban Crystallography of the 50S Ribosomal Subunit
10:00	Yan-Hui Liu Applications of Proteomics	Holger Stark 3D Structure Determination of Macromolecular Complexes by Electron Cryo-microscopy	Dusan Turk Lysosomal Cysteine Proteases	Ada Yonath Antibiotics Targeting the Ribosome
11:00	PP1s Come Down	BREAK	E X C U R S I O N
11:30	Kevin Shokat Use of Chemical Genetic Tools to Decipher Function	Brian Shoichet Hits, Leads, and Artifacts from Virtual & High-Impact of Genomic Sequencing and High Throughput Screening		Venki Ramakrishnan Functional Insights into the 30S Ribosomal Subunit from Antibiotic Interactions
12:30	LUNCH	PP2s Go Up		PP2s Come Down
14:30	W6: WHAT- CHECK ( in S. Rocco) W7: BioInformatics (in San Rocco) W8: Databases and Metal Ions (in S. Rocco)	Flemming Steen Jorgensen Ligand Selection and Design		John Markley NMR Spectroscopy
15:30		Christoff Sotriffer Crystal Structures as Knowledge Base for Docking and Design		Paula Fitzgerald Metallobetalactamases
16:30	BREAK
17:00	Peter Kuhn High Throughput Technologies for Structural Genomics	Group Discussions		Breaking News Fresh Pickings Michael Rossmann Structure and function of Dengue Virus
17:45	Vivian Stojanoff Structural Genomics at NSLS	Presentation of G2D Flow Chart Entries (information to be provided at Erice)		Breaking News Fresh Pickings
18:30	BREAK
19:00	Free Evening	Posters & Pasta (PP2)		Vendors Venue & buffet dinner (San Rocco)
20:00	Free Evening	Posters & Pasta (PP2)		Vendors Venue & buffet dinner (San Rocco)

Time	Saturday 1 June	Sunday 2 June
9:00	Vincent Mikol From 3D Structures to Drugs: Fxa and Deformylase Inhibitors	D E P A R T U R E
10:00	Michael Rossmann A Cure for Commom Cold : the Development of Pleconaril
11:00	BREAK
11:30	Gabriele Cruciani The design of DMPK properties
12:30	LUNCH
14:30	Richard Pauptit Trends and Strategies
15:30	G2D Flow Chart Winner
16:30	BREAK
17:00	Rounding up Discussions and Employment Perspectives * Summary and Awards
17:45
18:30	Free Time
19:00	Farewell Dinner
20:00	Farewell Dinner