9th Course : X-Ray Crystallography and Drug Design: Current Perspectives
21 March to 1 April 1983
Director : Alan S. Horn, Groningen
Purpose of the Course
It is more than sixty years since the discovery of the X ray diffraction by crystals, and crystallography has since established an ever widening sphere of influence in science. The solving of crystal structure has had an increasing impact in many fields - for example physics, chemistry, biology, materials science, medicine, metallurgy, mineralogy and geology.
Postgraduate courses at the "Ettore Majorana" Centre for Scientific Culture periodically review the advancement of crystallography. They usually concentrate onm interdisciplinary frotier topics. This course has a doublr purpose. On the one hand it will provide a review of the fundamentals and the application of crystallography, for pharmacologists and medical chemists and on the other an evaluation of the present state of our knowledge of receptors and drug-binding, for crystallographers. In addition, it is hoped that this exchange of viewpoints will lead to a better understanding of each other goals and to a closer collaboration between the two groups.
Topics (scientific sequence) and LECTURERS (alphabetic)
| Introductory X Ray Crystallography | F. ARCAMONE, Farmitalia, Milan, Italy |
| Crystal forces | V. AUSTEL, Thomae, Biberach, F. R. Germany |
| Host-guest complexes | C.R. BEDDELL, Welcome Laboratories, UK |
| Receptors | J. BERNSTEIN, Ben-Gurion University, Israel |
| Drug-receptor binding forces | C. BLAKE, University of Oxford, UK |
| Drugs and nucleic acids | T.L. BLUNDELL, Birkbeck College, London, UK |
| alpha-Helix dipole and electrostatic interactions | M. BRUFANI, University of Rome, Italy |
| Dihydrofolate reductase inhibitors | A: CAMERMAN, Univ. of Washington, Seattle, USA |
| Haemoglobin | S.F. CAMPBELL, Pfizer Research, Kent, UK |
| Prealbumine hormone complexes | C. DE RANTER, Universiteit Leuven, Belgium |
| Influenza virus haemagglutinin | W.L. DUAX, Medical Foundation, Buffalo, USA |
| Rigid drug analogues | P. GOODFORD, University of Oxford, UK |
| Folic acid | D.R.H. GOURLEY, E.Virginia Medical School, USA |
| Polypeptide hormones | P. GUND, Merck, Sharp and Dohme, USA |
| Steroids | T.A. HAMOR, University of Birmingham, UK |
| Benzomorphanes | W. HOL, University Groningen, Netherlands |
| Benzodiazepines | A.S. HORN, University Groningen, Netherlands |
| Antibiotics | P.A.KOLLMANN, UCLA, USA |
| Neuromuscolar blockers | G. MARSHALL, University Washington, Seattle, USA |
| Chemioterapeutic agents | H. MERZ, Boehringer Ingelheim, F.R. Germany |
| Drug conformation | S. NEIDLE, University of London, UK |
| Drug development | G. RICHARDS, University of Oxford, UK |
| Conformational analysis | D. SAVAGE, Organon, UK |
| Molecular modeling | J. TOLLENAERE, Janssens Pharmaceuticals, Belgium |
| Computers in drug design | K.N. TRUBLOOD, UCLA, USA |
| I.A. WILSON, Harvard University, USA |
Extracted from the orange announcement on Jan 3, 2008
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| On their knees, Lodovico, ??? D Savage ?, Ettore Sanfilippo, M. Armenia Carrondo, Norman Camermans, Joel Bernstein, ???, ???, ???; among those standing, after four unknown from the left side, Gabriella (cousin to Lodovico, helping with the organization), soon behind Manuela Scarsi (another helper), then Alan Horn - central - is easily recognized, having Pinola on his back, Piera Sabatino, Ingrid Kjoller Larsen, Ian Wilson, one ????, and finally at the wall Bill Duax. Behind Alan and Pinola, Peter Goodford; who has on his right, a bit far, Eric Hadicke, and behind Eric, Wim Hol; three heads on his right side, Peter Kollmann (passed). Then just a bit on the staircase, extreme right, you see Alessandro Vaciago (passed) and behind, Alberto Albinati. Behind Albinati, Davide Viterbo and Tom Blundell; one step further on his right, C. Blake and a smiling Paola. Up up, on the step where you see a big man with shoulders on the wall, Ken Trueblood(passed), a little further Christine Brempt and on the step in front of them, Trevor Petcher.. |